Objective: To characterise the antimicrobial resistance profiles of Klebsiella pneumoniae isolates from ICU patients in Baghdad tertiary care hospitals. Methods: A prospective cross-sectional study was conducted across three teaching hospitals between January and December 2025. A total of 184 K. pneumoniae isolates were recovered from blood, urine, and respiratory samples. Antibiotic susceptibility testing was performed using the Kirby-Bauer disc diffusion method and confirmed by MIC determination. Carbapenem-resistant isolates were screened for resistance genes by PCR. Results: Resistance rates to carbapenems reached 38.6% (71/184). The blaKPC gene was detected in 56.3% of carbapenem-resistant isolates. High rates of resistance were also observed for cephalosporins (82%) and fluoroquinolones (74%). Conclusions: The high prevalence of multidrug-resistant K. pneumoniae in Baghdad ICUs represents a significant public health concern requiring urgent antimicrobial stewardship interventions.