Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra. Curcumin, the principal bioactive compound of Curcuma longa, has demonstrated anti-inflammatory and antioxidant properties in multiple experimental models. Methods: We employed an MPTP-induced murine model to evaluate the neuroprotective potential of curcumin administered at doses of 50, 100, and 200 mg/kg body weight. Behavioural assessments including rotarod performance and open-field tests were conducted. Dopaminergic neuron counts and oxidative stress markers were quantified. Results: Curcumin at 200 mg/kg significantly attenuated MPTP-induced dopaminergic neurodegeneration (p < 0.01), improved motor performance, and reduced malondialdehyde levels by 42% compared to untreated controls. Conclusions: These findings suggest that curcumin exerts dose-dependent neuroprotective effects in PD models, warranting further investigation into its translational potential.